Alpha-lipoic acid, a naturally occurring compound and a radical scavenger has been shown to enhance glucose transport and utilization in different experimental and animals models. The effects of a four-week oral treatment with alpha-lipoic acid were evaluated in a placebo-controlled study to determine whether oral treatment also improves insulin sensitivity. Seventy-four patients with type-2 diabetes were randomly given either placebo or active treatment in various doses of alpha-lipoic acid. When compared to placebo, significantly more subjects had an increase in insulin-stimulated glucose uptake after alpha-lipoic treatment. This study confirms previous observations of an increase in insulin sensitivity in type-2 diabetes patients after acute and chronic intravenous administration of alpha-lipoic acid. The results suggest that oral administration of alpha-lipoic acid can improve insulin sensitivity in patients with type-2 diabetes.
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[Muscular Development, Vol. 36, Number 12, December 1999, "Insulin Sensitivity Improved in Type-2 Diabetes, pg. 56]
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