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Nutritional Support For Depression

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SAMeWhat Makes SAMe Different?

SAMe (S-adenosyl-methionine) is an amimo acid derivative normally synthesized in the body. It is widely used in Europe as an antidepressant. There is evidence that SAMe may be the fastest acting, safest and most effective antidepressant available; may help prevent and reverse liver disease; may be effective in the treatment of fibromyalgia, chronic fatigue syndrome and osteoarthritis; and may help to synthesize phosphatidylcholine, which helps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine.

CAUTION: Do not use SAMe with other antidepressants. At levels above 400 mg daily, SAMe may cause dry mouth, restlessness and gastrointestinal problems. Cutting back on dosage and than increasing it slowly should alleviate these symptoms.

Product #8358
(20 tablets)

Nutritional Information
2 Tablets Contain:
S-Adenosyl-Methionine 400 mg *
Other Ingredients: Cellulose, Mannitol, Hydroxpropyl Methylcellulose Phthalate, Citric Acid, Sodium Starch Glycolate, Glyceryl Triacetate, Croscarmellose Sodium, Stearic Acid, Silica, Titanium Dioxide, Yellow Ochre.

RDI - Reference Daily Intake
* - RDI not established

Suggested Use: As a dietary supplement, take one tablet before meals in the morning and one in the afternoon. This may be increased by taking one tablet in the morning and two tablets in the afternoon, and for some people, an additional tablet in the evening. After two weeks, a maximum dose of two tablets in the morning, two in the afternoon, and two in the evening can be taken. One bottle provides a 10 day supply.

Caution: When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition.

**Nutritional Information may vary slightly from actual product label due to recent changes in labeling laws.

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These statements have not been evaluated by the Food & Drug Administration.   This Product is not intended to diagnose, treat, cure or prevent any disease.

Facts About Depression

Medical textbooks describe depression as a mood disorder, lasting at least 2 weeks, that produces exagerated, inappropriate feelings of sadness, worthlessness, emptiness, and dejection. "Exagerated" and "inappropriate" are two important words to keep in mind. To feel upset because of a job layoff, a broken marriage, a bankruptcy, or the loss of a loved one is a perfectly normal response to an unhappy event. Generally, our upset feelings are proportional to our loss, and this "reactive depression," as doctors call is, goes away with time.

However, major depression often strikes for no apparent reason. It doesn't seem to be caused by outside events. Instead, the black mood grows and grips from within. This crippling darkness can last for weeks, months, or years, and may make it impossible for us to carry on our normal lives.

Although we're only beginning to pull back the curtains that hide the inner workings of the human brain, we do know that several neurotransmitters (chemical messangers), including norepinephrine and serotonin, help to regulate our moods and keep us happy. Depressed people tend to have lower levels of norepinephrine and serotonin. If, for any reason, the amounts of these key neurotransmitters drop below critical levels, the result may be major depression that seems to come from nowhere, linger forever, sap our energy, and ruin our lives.

Why do brain levels of mood regulators fall in some people but not in others? We can't fully answer that question, although we know that genetics plays a major role. Depression, like other mood disorders, tends to run in families. Depression is even more likely to be shared by identical twins: if one is depressed, there's a better than 50% chance that the other will be, too.

A great deal of research has looked into possible environmental and psychological causes of depression. Some investigators believe that people who are pessimistic, often fell overwhelmed by life, or have low self-esteem are more likely to suffer from depression. It may be that some of us are lucky enough to have large reserves of "happy" neurotransmitters in our brains, but others have just enough to keep a smile on their faces.

Although biochemistry is the biggest factor in major depression, we're also affected by what happens to us in our lives. We're all hit by unpleasant events that may cause brain levels of norepinephrine and dopamine to fall temporarily. People with naturally large reserves will get through the troubling times wiht minimal difficulties, but those with low chemical levels to begin with are more likely to fall into a depression.

Excerpt from Depression and Stress Relief in The Directory of life Extension Supplements, 2000, pg 86.

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